NCATS Advisory Council Convenes
Unique NASA Research Opportunity
The National Aeronautics and Space Administration (NASA)
Human Research Program (HRP) is releasing a Cooperative Agreement Notice
(CAN) for the Translational Research Institute. On or about September 16,
2015, this Draft CAN will be available electronically through the HRP
Translational Research Institute website by selecting Draft Cooperative
To read more about this opportunity, please click here. Direct
questions specifically regarding this solicitation should be sent to Lawrence Miller, Contracting
Officer ph: 281-483-3916 or Barbara
Corbin, HRP/Deputy Director, ph: 281-483-6215.
News From the Hill--ACTS Advocacy News
Senate and House Produce FY 2016 LHHS Appropriations Bills
As Congress returns following the August recess, lawmakers face a growing
list of legislative priorities that will require some action before the end
of the year. Most pressingly, with the fiscal year (FY) set to begin on
October 1st, legislators will need to move forward with appropriations for
FY 2016. The most likely scenario is the passage of a short-term Continuing
Resolution that will temporarily level-fund federal programs and buy
lawmakers time to work on the spending bills before completing them later
this year. It is also possible that a budget deal might be reached in the
near future that would allow Congress to increase spending in the
appropriations bills. Such action would allow for more generous allocations
for public health and medical research programs in FY 2016.
As it currently stands, the National Institutes of Health (and the CTSA and
IDeA) programs are poised for FY 2016 funding increases while the Agency
for Healthcare Research and Quality may take a funding cut without
additional authorized spending.
Read more details by clicking on the ACTS
ACTS Member Highlight Coming in September
In the next issue of ACTS Connection, read how:
Mark Walter, Ph.D., professor of microbiology in the University of Alabama
at Birmingham School of Medicine, is seeking a way to detect at the level
of individual immune cells — exactly which interferons and which
cells provoke the disease. This ability would help develop blood tests to
diagnose the disease and also measure the effectiveness of lupus
Share Your Exciting News Stories With Us! Does your institution have news
you want to share with the ACTS Connection readership? Do you have
an investigator doing something innovative? Let us know! From innovative
projects, star scholars and trainees, to award winning faculty, help us
share the news that is important to you by submitting it through our online form.
Your news may be shared on the ACTS website, and other ACTS social media
Save the Date Now for Translational Science 2016
Translational Science News
HHS Announces Proposal to Update Rules Governing Research
on Study Participants
NIH Grants Seek Best Ways to Combine Genomic Information
Closer Collaboration Among Researchers, Execs Needed
15-Year-Old 'Transparency' Effort Seems to Curb Dubious
Research Centers for Cancer Systems Biology Consortium
BRAIN Initiative: Short Courses in Computational
NINDS Advanced Postdoctoral Career Transition Award to
Promote Diversity in Neuroscience Research (K22)
Save the Date Now
for Translational Science 2016
Mark Your Calendars! Translational Science 2016 will take place April 13-15
at the Omni Shoreham Hotel in Washington, DC. Registration for
Translational 2016 is expected to open in December 2015.
Announces Proposal to Update Rules Governing Research on Study Participants
The Department of Health and Human Services has proposed revisions to
regulations meant to protect individuals who participate in research. The
Notice of Proposed Rulemaking, issued on Sept. 2, includes changes such as strengthened
informed consent provisions, new data-security and information-protection
standards, and requirements for written consent for use of an individual's
biological samples. The proposed changes would apply to all clinical trials
conducted in a U.S. institution that receives funding for research
involving human participants from a Common Rule agency.
From "HHS Announces Proposal to Update Rules Governing Research on
HHS News Release (09/02/15)
Grants Seek Best Ways to Combine Genomic Information and EHRs
The National Institutes of Health has awarded 12 grants to support research
that incorporates DNA sequence information into electronic medical records.
Research by the Electronic Medical Records and Genomics (eMERGE) network
aims to better understand the genomic basis of disease and to tailor
individual medical care based on genetics. The grants were administered by
the National Human Genome Research Institute and represent the third phase
of the eMERGE program, which includes identifying the potential medical
effects of rare genomic variants in about 100 clinically relevant genes.
From "NIH Grants Seek Best Ways to Combine Genomic Information and EHRs"
NIH News (09/01/15)
Collaboration Among Researchers, Execs Needed
Improvements in health services, patient outcomes, and consumer experiences
will need greater collaboration between healthcare leaders and researchers,
but there are still barriers to integrating research and practice due to
gaps between research approaches and delivery system needs. Many healthcare
executives say that integrating research with care delivery could support
organizational goals, use data to drive decision-making, and strengthen
delivery-system reputation and community connections. Healthcare researchers
may consider participating in opportunities such as pragmatic clinical
trials and "big data" networks, which may help reduce the
disconnect between current healthcare research and delivery system demands,
write Dr. Eric Larson, executive director of the Group Health Research
Institute, and Karin Johnson, a research associate in the MacColl Center
for Health Care Innovation at the institute.
From "Closer Collaboration Among Researchers, Execs Needed"
Modern Healthcare (08/22/15) Larson, Eric; Johnson, Karin
'Transparency' Effort Seems to Curb Dubious Biomedical Findings
A PLoS ONE study suggests that the ClinicalTrials.gov registry, launched in
2000, has had a significant impact on reported trial results. In a sample
of 55 large trials testing heart-disease treatments, 57 percent of trials
published before 2000 reported positive effects from the treatments, but
only 8 percent reported positive effects after 2000. Study author Veronica
Irvin, a health scientist at Oregon State University, says the findings
suggest that registering clinical studies has made research more rigorous.
Irvin and co-author Robert Kaplan, chief science officer at the Agency for
Healthcare Research and Quality, note that trial registration appears to be
a key factor in the study results, as there was no evidence that the change
was caused by fluctuating levels of industry sponsorship or differences in
From "15-Year-Old 'Transparency' Effort Seems to Curb Dubious
Scientific American (08/20/15) Woolston, Chris
Centers for Cancer Systems Biology Consortium (U54)
The National Cancer Institute (NCI) will fund a new Cancer Systems Biology
Consortium (CSBC) that aims to address challenges in basic and
translational cancer research. In a funding opportunity announcement, NCI
invites U54 cooperative agreement applications for CSBC Research Centers
that use systems biology approaches to build predictive models of cancer
initiation, progression and metastasis. The centers will consist of interdisciplinary
teams of scientists and cancer researchers. The NCI intends to commit up to
$12.6 million each fiscal year through 2018 for new U54 awards, and a total
of 8-10 awards is anticipated. Applications are due by Nov. 20, 2015.
From "Research Centers for Cancer Systems Biology Consortium
NIH Grants (09/02/15)
Initiative: Short Courses in Computational Neuroscience (R25)
The National Institutes of Health's Research Education Program has issued a
funding opportunity announcement (FOA) to accomplish the goals of the Brain
Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative.
This program aims to support educational activities that enhance the
training of a workforce to meet biomedical, behavioral, and clinical
research needs. This FOA will support creative educational activities,
focusing especially on Courses for Skills Development. The BRAIN Initiative
intends to commit about $1 million in the 2016 fiscal year to fund five
awards. The application due date is Nov. 6, 2015.
From "BRAIN Initiative: Short Courses in Computational Neuroscience
NIH Grants (08/28/15)
Advanced Postdoctoral Career Transition Award to Promote Diversity in
Neuroscience Research (K22)
The National Institute of Neurological Disorders and Stroke (NINDS) has
announced the NINDS Advanced Postdoctoral Career Transition Award to
Promote Diversity. This grant is designed to enhance the participation of
highly trained early career investigators from diverse backgrounds that are
underrepresented in neuroscience research. The National Institutes of
Health will contribute up to $95,000 commensurate with salary and effort
during Phase II. In Phase I, the agency will contribute salary commensurate
with the applicant institution's salary structure, up to $50,000 per year.
Individuals are eligible for support under this award if they have doctoral
research degrees and two to five years of postdoctoral prior research
training. Applications are due by Feb. 12, 2016.
From "NINDS Advanced Postdoctoral Career Transition Award to Promote
Diversity in Neuroscience Research (K22)"
NIH Grants (08/25/15)
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